Critical Reviews in Oncology/Hematology 42 (2002) 309 315 www.elsevier.com/locate/critrevonc
te complexes in cancer treatment
Enrique Melendez * ´
Department of Chemistry, Mayaguez Campus, P.O. Box 9019, Mayaguez, Puerto Rico 00681 ¨ recognized 27 June 2001 To my children, Gustavo, Mariana and Gabriel, the greatest inspiration of my life
Contents
1. Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2. Titanium complexes with antitumor military action 2.1. Bis(b-diketonato)titanium complexes . . 2.2. Titanocene complexes . . . . . . . . . . 2.2.1. Cp2TiX2 diacido complexes . . . 2.2.2. Ionic titanocene complexes. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 310 310 310 311 311 311 312 312 314 314 314 314 315
3. Hydrolysis of metal complexes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4. Binding studies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5. General remarks . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . Reviewers . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Acknowledgements . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Biography. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Abstract A series of complexes containing titanium, Ti, as a metal center has shown to make a wide spectrum of antitumor properties. This series belongs to the non-platinum metal antitumor...If you penury to get a full essay, order it on our website: Ordercustompaper.com
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